Applied Trophology, Vol. 1, No. 5
(May 1957)

The Management of the Hypercholesterol Patient

The following is a transcription of the May 1957 issue of Dr. Royal Lee’s Applied Trophology newsletter, originally published by Standard Process Laboratories.

Also in this issue:

  • Tip of the Month (Menopausal Hot Flashes)
  • Pharmacology and Physiology of Vitamin Action
  • Book Review (The Pulse Test by Arthur F. Coca)

The Management of the Hypercholesterol Patient

Recent reports show conclusively that hydrogenated fats are a common cause of high blood cholesterol, which is a concomitant state in many chronic and serious disease syndromes from cancer to eclampsia. (Diabetes, hypertension, many cardiovascular diseases, biliary obstructions, nephritis, nephrosis, and lupus erythematosus are a few.) It is probable that cholesterol is a secondary, not a primary, reaction but may bring in many side reactions that can contribute to a fatal ending. For instance, diabetic coma is attributed to the high blood fat and cholesterol that occurs parallel to the high sugar.

Cholesterol estimation is considered a better index of the severity of diabetes than sugar estimation in blood.1

Cholesterol has important physiological functions. It contributes structurally to the cell wall and semipermeable membrane construction. This is why a cholesterol excess may result in hypertension—too much pressure is compensatively necessary to force the normal diffusion of fluid out of the capillary bed. Without this diffusion cell nutrition is impossible. Drugs that lower the blood pressure without improving the permeability make the patient symptomatically worse.

Hyaluronidase, the so-called physiological “spreading factor,” is one regulator of permeability and is the active principle of Orchex. Orchex often is invaluable in stubborn hypertension but may not always be a complete remedy, simply again for the same reason that not all diabetics respond fully to insulin. (Orchex should be considered, we believe, a “physiological tranquilizer” for both sexes. In fact, the female seems to react more favorably than the male when it is used for nervous insomnia, “butterfly stomach,” and other such conditions.)

Histamine may be a factor in hypertension, so the liver antihistamine Anti-Pyrexin [Antronex] may be important. (This was formerly sold as Anabolin, well known as a hypertension remedy.)

The source of histamine must be nucleoprotein waste products, otherwise known as “purines,” backed up because of kidney or liver incompetence or degeneration. (Nucleoproteins are eliminated by both routes, under the control of the pineal gland, which secretes two hormones, one directing elimination by the liver, the other by the kidney. It is of interest to see that pineal has been successfully used to treat gastric and duodenal ulcer, for excess histamine has been considered a cause of such ulcers—Gerson, H.M., Acta Med. Scandia., 145(5): 370–375, 1953.)

Our recommendation is Pituitary Cytotrophic Extract [Pituitrophin PMG], which we believe acts by restoring a more normal sex hormone balance, which has resulted in a delayed healing reaction. But sex hormones have a lot to do too with histamine, via their regulation of the kidney and liver and elimination of purines—the male hormone increasing kidney arginase, the female hormone increasing liver arginase.

Organic manganese (available as Manganese Glycerophosphate [E-Manganese] from Standard Process) is an activator of arginase, another possible deficient factor. Arginase (as Arginex) has been found clinically invaluable in treating nephrosis. Nephrosis is characterized by a very high blood cholesterol. We believe this blood cholesterol is in the nucleoprotein waste or toxin complex that arises from nucleoprotein of both endogenous and exogenous source. It has backed up because of the inability of the kidney to eliminate it, according to this hypothesis. The same thing would be true in eclampsia. Very probably we shall find use for Arginex in taking the load off the kidney in these toxic states as well as in nephrosis.

Nucleoproteins are normal tissue waste products, but meat-eating greatly increases the amount to be eliminated (up to 300 percent). That is why it is dangerous for old people to suddenly be converted to a high animal protein diet. Often, they collapse from liver and kidney complications too quickly to be saved.

The commonest complaint involving cholesterol excess is gallbladder congestion and gallstones, which are cholesterol “stones.” The cause seems to be a lack of the factors necessary for keeping cholesterol in suspension in the bile. The use of the product A-F and Betaris [A-F Betafood] (vitamin complexes A and F with dehydrated beet leaf juice) is highly successful in controlling the symptoms of distress in these cases. Physicians have reported to us their ability to treat such patients consistently without operative procedures. In fact, operations do no more than temporarily ameliorate the condition. Stones often form in the liver ducts after gallbladder removal and cause great pain, often simulating gastric ulcer, angina pectoris, etc., by reflected nerve stimulation.

Relief is immediate as a rule, but a long schedule of dosage is desirable; the liver deserves better attention than most of us give such an important organ. Dietary fat restriction is important; allergic sensitivities must be suspected—milk often is an offender. Strawberries rank high too as an allergen. (Note review below of The Pulse Test.)

The kidney and pancreas must not be forgotten. Both secrete hormonal factors that have to do with cholesterol control (see p. 3, Applied Trophology, Vol. 1, No. 2 for data on the pancreas factor), so the respective cytotrophic extracts may be important if these organs are damaged.

Vitamin F complex is the anti-cholesterol factor of the natural oils and is the most important protective factor in our food intake.

Chlorophyll is known to lower blood cholesterol.2 Also in this category is montmorillonite, since it absorbs cholesterol selectively and no doubt acts to fix it in the intestinal tract, so it cannot be reabsorbed. Bentonite has a similar effect. (Antiphlogistine in the drugstore is another simple product used externally.)

Sitosterol, a factor refined from soybean oil, is being sold as a cholesterol controlling factor. George L. Curran, MD, has pointed out the fallacy of this procedure, which lowers blood cholesterol temporarily but fails to alter the state of overloaded tissues that represents the true pathological condition. He says, “Because a compensatory increase in cholesterol synthesis will always prevent more than a transitory reduction in tissue cholesterol induced by other means, as in the case of the rats fed soy sterols, the future treatment of atherosclerosis must of necessity include some inhibitor of cholesterol synthesis” (Am. Pract. & Digest of Treatment, 7:1412–1417, 1956).

Curran points out the fallacy also of restricting the intake of natural foods such as butter and eggs in the futile effort to alter the situation.

The real factor in the soy oil that lowers tissue cholesterol as well as the blood cholesterol level is the vitamin F complex in the natural unrefined fats, not the vegetable sterol. (See Vitamin News for the complete story of this vitamin complex; see also Lee Foundation Reports Nos. 1 and 3.) Here we find, according to Dr. Hugh M. Sinclair of Oxford University, that the deficiency of the vitamin F complex (by reason of losses in foods from oxidation, flour bleaching, hydrogenation of oils, etc.), the body becomes sensitized to carcinogens, to sunlight, and to cholesterol, all of which can then, and then only, perform their devastating damage.

Dr. Sinclair says such sensitized animals (and of course human subjects) are “walking invitations to disaster.” That is why test animals on a controlled vitamin E deficient diet (the antioxidant action of which protects vitamin F) invite the disaster of having thirteen out of twenty-eight drop dead within one year on such a diet. (See Annals of N.Y. Academy of Science, Vol. 52, p. 256.)

Therefore, the basic remedy for high blood cholesterol is vitamin F, vitamin F2 if the liver is damaged (indicated by underweight and no appetite), fresh wheat germ oil, and fresh, unrefined vegetable oils (soy, sesame, peanut) in the dietary pattern. Also, avoid stale cereal products and do not use packaged breakfast food, bread, or pastry unless made with fresh ground flour (whether wheat, corn, or rye). In all such products, the oils become rancid within days of their grinding unless refrigerated.

Vitamin G complex is second on the list. It aids the liver in its fat metabolism and is the primary remedy if a coronary attack has occurred or if the skin lesions of pellagra are present (including psoriasis). Its potency is demonstrated by the usual effect on papilloma, whether on skin as warts, on eyelids, on heart valves, causing stenosis, or in the bladder, causing obstruction to fluid exit.

The potency of the vitamin F complex is demonstrable by its effect in restoring the missing second sound of the heart, often a result of a combined deficiency of calcium bicarbonate in the blood with the F complex deficiency. Calcium Lactate plus a tablet or two of this vitamin restores the second sound within ten minutes. How? By promoting the diffusion of calcium bicarbonate to the starving heart muscle (and the cardiovascular system as a whole) and thus promoting its normal contraction, which had been collapsing before completion of the systole.


  1. Biological & Clinical Chemistry, p. 679–680. Lea & Febiger, 1937.
  2. Gordonoff, T. “Effect of Chlorophyll on Cholesterol Metabolism & Cholesterol Sclerosis.” med. Wochenschr, 19:459, 1933.

Tip of the Month (Menopausal Hot Flashes)

The hot flashes of menopause respond best to Organic Iodine [Prolamine Iodine] and Vitamin F [Cataplex F Tablets]. (Wheat Germ Oil in some cases is synergistically important.) The condition is due to excess thyrotropic hormone from a pituitary gland that has lost the inhibiting influence of the ovary.

The Pharmacology and Physiology of Vitamin Action

The physiological action of a vitamin is its normal effect in the maintenance of health. The pharmacological action is the effect of abnormally high doses (non-nutritional action), and the effect of isolated fractions in pure forms or synthetic forms where it differs from the action of the normal vitamin. A good example of this is the effect of nicotinic acid as a vasodilator, an effect never shown by natural fractions of the vitamin B complex.

The pharmacological action is the drug effect of a vitamin; the physiological effect is the nutritional effect. In the case of some synthetic vitamins—viosterol, for example—there seems to be no physiological effect without some toxic or drug effect (in this case not wanted), the effect of causing in some degree calcification of kidney and other soft tissue. The natural forms of vitamin D (such as cod liver oil) have never been known to cause any toxic action.

To get a specific physiological action from a vitamin, it is often necessary to split up a vitamin complex into its various fractions. For instance, one fraction of the vitamin E complex (E2) has almost the exact effect of nitroglycerin in relaxing vascular musculature and in stopping the pains of angina pectoris.

Book Review: The Pulse Test by Arthur F. Coca

No doctor who aspires to physiological therapy can afford to overlook the book The Pulse Test by Arthur F. Coca, MD.

Dr. Coca discovered that the pulse count rises after a meal in which some item was creating an allergic reaction. (This is probably the same reaction to cooked protein residues that Kouchakoff found creates a leukocyte increase after meals, such a reaction never following the ingestion of raw foods.)

Dr. Coca’s first successful patient was his wife, who lost a stubborn angina pectoris condition as soon as she eliminated the offending foods from her nutritional schedule. He has since found the following disorders respond to his method: high blood pressure, recurrent headaches, asthma, chronic fatigue, ulcers, hemorrhoids, eczema, multiple sclerosis, and others.

It is of interest that Dr. Coca’s pulse test pinpoints aluminum poisoning, which he found could cause long-standing colitis.

Also, of interest is that Dr. Coca is not alone in attributing serious heart disease to allergy. Dr. Joseph Harkavy of New York reported to the Second World Congress of Cardiology in Washington in September 1954 that coronary disease, heart muscle damage, and angina pectoris could result from allergy to tobacco, penicillin, bacteria, and some foods.

(We remind you that allergies are aggravated greatly by alkalosis—see Applied Trophology, Vol. 1, No. 2).


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